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H286

Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.

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Specificaties

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

Algemene informatie

Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery.

This specific variant of the disease is found in the Labrador Retriever. Other variants are found in multiple breeds, such as the German Shepherd, Rhodesian Ridgeback and Irish Setter.

Klinische eigenschappen

Common clinical signs in dogs include bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.

Extra informatie

Referenties

Pubmed ID: 37438956

Omia ID: 437