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Hypertrophic Cardiomyopathy (HCM) is a serious disorder characterized by an enlarged heart, which can lead to weakness, fatigue and (potentially fatal) heart failure.
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Specificaties
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Algemene informatie
Hypertrophic Cardiomyopathy (HCM) is a serious disorder characterized by an enlarged heart, which can lead to weakness, fatigue and (potentially fatal) heart failure. The variant of the disease analysed in this test, found in domestic shorthaired cats, is associated with a dominant mutation to the gene MYH7.
Klinische eigenschappen
HCM is a thickening of the heart muscle that can result in decreased heart function, heart murmur and abnormal heart rhythm. Clinical signs of heart failure due to HCM include shortness of breath, fluid behind the lungs, fatigue, exercise intolerance, loss of appetite, and sometimes sudden death due to cardiac arrest. Cats with HCM are more likely to develop thromboembolism (blood clots), especially in the hind legs. This causes bluish discoloration of the paw pads, inability to use the hind legs and extreme pain.
Extra informatie
The mutation in this test should be considered a risk factor. It is associated with the disorder, but does not necessarily guarantee it.
Referenties
Pubmed ID: 31164718
Omia ID: 2212